Moduretic: Uses, Active Ingredients, And Synonyms

Moduretic is a medication used to treat high blood pressure and fluid retention. It is a combination of two active ingredients – amiloride and hydrochlorothiazide – that work together to relax the blood vessels, reduce the amount of water in the body, and reduce blood pressure. The drug was first approved by the Food and Drug Administration (FDA) in 1981.

Moduretic is used to treat hypertension, or high blood pressure. It works by blocking the action of certain hormones in the body that cause the blood vessels to constrict, which can lead to high blood pressure. It also helps to reduce the amount of fluid in the body, which can help to reduce swelling and edema. Additionally, Moduretic can help to reduce the risk of stroke and heart attack.

Moduretic is also used to treat edema, or fluid retention, which can be caused by certain medical conditions such as congestive heart failure and liver or kidney disease. It works by helping the body to get rid of excess water and salt. This can help to reduce swelling and improve symptoms.

The active ingredients in Moduretic are amiloride and hydrochlorothiazide. Amiloride is a potassium-sparing diuretic, which means it helps to reduce the amount of salt and water in the body without affecting the amount of potassium. Hydrochlorothiazide is a thiazide diuretic, which helps to reduce the amount of water in the body by increasing the amount of urine produced.

Other names for Moduretic include Midamor, Amamode and Moduret. The drug is available in tablet form and is usually taken once or twice daily. Common side effects of Moduretic include nausea, dizziness, headache, diarrhea, and muscle cramps.

Moduretic has been used to treat high blood pressure and fluid retention since it was first approved by the FDA in 1981. It is a safe and effective medication when taken as directed. However, it is important to talk to your doctor if you have any questions or concerns about the use of Moduretic.


1. Food and Drug Administration. (2021). Moduretic. Retrieved from

2. Mayo Clinic. (2021). Moduretic. Retrieved from

3. WebMD. (2021). Moduretic. Retrieved from

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